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Glaucocalyxin A

Names

[ CAS No. ]:
79498-31-0

[ Name ]:
Glaucocalyxin A

[Synonym ]:
ent-7,14-Dihydroxy-16-kauren-3,15-dione
Glaucocalyxin A
(5β,7α,8α,9β,10α,13α,14R)-7,14-Dihydroxykaur-16-ene-3,15-dione

Biological Activity

[Description]:

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

PI3K

Akt


[In Vitro]

Glaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3[1].

[References]

[1]. Zhu J, et al. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nucleartranslocation via regulating PI3K/Akt pathway. Cell Death Dis. 2018 Jun 13;9(6):708.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
513.4±50.0 °C at 760 mmHg

[ Melting Point ]:
219.5-220.5℃

[ Molecular Formula ]:
C20H28O4

[ Molecular Weight ]:
332.434

[ Flash Point ]:
278.4±26.6 °C

[ Exact Mass ]:
332.198761

[ PSA ]:
74.60000

[ LogP ]:
0.88

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.574

[ Storage condition ]:
2-8°C

Related Compounds