BIBU1361

Names

[ Name ]:
BIBU1361

[Synonym ]:
bibu 1361 dihydrochloride
bibu 1361

Biological Activity

[Description]:

BIBU1361 induces apoptosis and inhibits autophagy. BIBU1361 inhibits pro-survival pathways Akt/mTOR and gp130/JAK/STAT3, and decreased levels of pro-inflammatory cytokine IL-6[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[References]

[1]. Ruchi Ghildiyal, et, al. EGFR inhibitor BIBU induces apoptosis and defective autophagy in glioma cells. Mol Carcinog. 2013, 52,12.

Chemical & Physical Properties

[ Boiling Point ]:
663.5ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₇ClFN₇

[ Molecular Weight ]:
443.95

[ Flash Point ]:
355.1ºC

[ Exact Mass ]:
515.15300

[ PSA ]:
70.07000

[ LogP ]:
6.25610

Related Compounds

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