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Echinosporin

Names

[ CAS No. ]:
79127-35-8

[ Name ]:
Echinosporin

[Synonym ]:
echinosporine

Biological Activity

[Description]:

Echinosporin (XK-213) is an antibiotic. Echinosporin can be isolated from Amycolatopsis strain. Echinosporin has antifungal activity and antitumor activity[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal
Research Areas >> Inflammation/Immunology

[Target]

MIC50: 64 μg/mL (Fusarium oxysporum); 64 μg/mL (Fusarium solani); 32 μg/mL (Alternaria panax); 64 μg/mL (Phoma herbarum)[2].


[In Vitro]

Echinosporin (XK-213) 对革兰氏阳性和阴性微生物表现出较弱的抗菌活性，并具有抗肿瘤活性[1]。 Echinosporin 对三七根腐病病原体具有抗真菌活性，包括 Fusarium oxysporum、Fusarium solani、Alternaria panax 和 Phoma herbarum，MIC50 值 分别为 64、64、32 和 64 μg/mL[2]。

[References]

[1]. T Sato, et al. A new antibiotic echinosporin (XK-213) - producing organism, isolation and characterization. J Antibiot (Tokyo). 1982 Mar;35(3):266-71.  

[2]. Xindong Xu, et al. Echinosporin antibiotics isolated from Amycolatopsis strain and their antifungal activity against root-rot pathogens of the Panax notoginseng. Folia Microbiol (Praha). 2019 Mar;64(2):171-175.  

Chemical & Physical Properties

[ Density]:
1.709g/cm3

[ Boiling Point ]:
635.1ºC at 760 mmHg

[ Molecular Formula ]:
C10H9NO5

[ Molecular Weight ]:
223.18200

[ Flash Point ]:
337.9ºC

[ Exact Mass ]:
223.04800

[ PSA ]:
98.85000

[ Index of Refraction ]:
1.687

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JW5313000
CHEMICAL NAME :
Echinosporin
CAS REGISTRY NUMBER :
79127-35-8
LAST UPDATED :
198509
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H9-N-O5
MOLECULAR WEIGHT :
223.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
54 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 35,266,1982

Related Compounds

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