DB818

Names

[ Name ]:
DB818

Biological Activity

[Description]:

DB818 (DB-818, DB 818) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence; directly bind to HOXA9-cognate sequence with Kd value of 4.6 nM (HBS sequence); alters HOXA9-mediated transcription, cell survival and cell cycle inHOXA9-mediated HOXA9-expressing murine MigA9 cell line.

[References]

References 1. Depauw S, et al. J Med Chem. 2019 Jan 15. doi: 10.1021/acs.jmedchem.8b01448. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₆N₆S

[ Molecular Weight ]:
360.439

Related Compounds

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