Name | DB818 |
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Description | DB818 (DB-818, DB 818) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence; directly bind to HOXA9-cognate sequence with Kd value of 4.6 nM (HBS sequence); alters HOXA9-mediated transcription, cell survival and cell cycle inHOXA9-mediated HOXA9-expressing murine MigA9 cell line. |
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References | References 1. Depauw S, et al. J Med Chem. 2019 Jan 15. doi: 10.1021/acs.jmedchem.8b01448. View Related Products by Target Other Targets |
Molecular Formula | C19H16N6S |
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Molecular Weight | 360.439 |