<Suppliers Price>

GW284543

Names

[ CAS No. ]:
790186-68-4

[ Name ]:
GW284543

Biological Activity

[Description]:

GW284543 (UNC10225170) is a selective MEK5 inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> MEK

[Target]

MEK5


[In Vitro]

GW284543 (UNC10225170) treatment dose dependently inhibits MEK5, as determined by reductions in pERK5, and decreased endogenous MYC protein[1].

[References]

[1]. Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H20N2O3

[ Molecular Weight ]:
372.42

[ Storage condition ]:
2-8℃