Isobutylamine
Names
[ CAS No. ]:
78-81-9
[ Name ]:
Isobutylamine
[Synonym ]:
i-Butylamine
Isobutylamine
iso-C4H9NH2
Valamine
Isobutylamin
Isobtuylamin
2-methylpropan-1-amine
IBA
isobutyl amine
MFCD00008146
MIBA
EINECS 201-145-4
Chemical & Physical Properties
[ Density]:
0.736 g/mL at 25 °C(lit.)
[ Boiling Point ]:
64-71 °C(lit.)
[ Melting Point ]:
−85 °C(lit.)
[ Molecular Formula ]:
C4H11N
[ Molecular Weight ]:
73.13680
[ Flash Point ]:
15 °F
[ Exact Mass ]:
73.08910
[ PSA ]:
26.02000
[ LogP ]:
1.30140
[ Index of Refraction ]:
n20/D 1.397(lit.)
[ Water Solubility ]:
soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NP9900000
- CHEMICAL NAME :
- Isobutylamine
- CAS REGISTRY NUMBER :
- 78-81-9
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C4-H11-N
- MOLECULAR WEIGHT :
- 73.16
- WISWESSER LINE NOTATION :
- Z1Y1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 224 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Behavioral - antipsychotic
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 63,150,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:STEL 5 ppm (15 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 25 ppm (75 mg/m3) JAN 1993
Safety Information
[ Symbol ]:
GHS02, GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H301-H314
[ Precautionary Statements ]:
P210-P280-P301 + P310-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive
[ Risk Phrases ]:
R11;R22;R35
[ Safety Phrases ]:
S26-S36/37/39-S45
[ RIDADR ]:
UN 1214 3/PG 2
[ WGK Germany ]:
1
[ RTECS ]:
NP9900000
[ Packaging Group ]:
II
[ Hazard Class ]:
3
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Pharm. Biomed. Anal. 117 , 316-24, (2015)
Supercritical fluid chromatography (SFC) has long been a preferred method for enantiopurity analysis in support of pharmaceutical discovery and development, but implementation of the technique in regu...
The development of a semi-preparatory scale supercritical-fluid chromatograph for high-throughput purification of 'combi-chem' libraries.J. Biochem. Biophys. Methods 43(1-3) , 87-111, (2000)
A unique separator was developed which allowed automatic separation and peak collection using semi-preparative supercritical fluid chromatography (SFC). A peak detector switched the effluent between w...
Effect of particle size on the speed and resolution of chiral separations using supercritical fluid chromatography.J. Chromatogr. A. 1363 , 250-6, (2014)
Fast chiral supercritical fluid chromatography (SFC) separations have become important due to the increasing use of high-throughput experimentation (HTE) in organic synthesis. These HTE experiments ca...