Butyrolactone 3

Names

[ Name ]:
Butyrolactone 3

[Synonym ]:
Butyrolactone 3
3-Furancarboxylic acid, tetrahydro-4-methylene-5-oxo-2-propyl-, (2S,3R)-
(2S,3R)-4-Methylene-5-oxo-2-propyltetrahydro-3-furancarboxylic acid

Biological Activity

[Description]:

Butyrolactone 3 is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)[1]

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

[Target]

GCN5:100 μM (IC50)

[References]

[1]. Biel M,et al. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
386.2±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₂O₄

[ Molecular Weight ]:
184.189

[ Flash Point ]:
158.5±21.4 °C

[ Exact Mass ]:
184.073563

[ PSA ]:
63.60000

[ LogP ]:
0.99

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.495

[ Storage condition ]:
-20°C

Related Compounds

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