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Oglemilast

Names

[ CAS No. ]:
778576-62-8

[ Name ]:
Oglemilast

[Synonym ]:
Oglemilast [INN]
N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide
Oglemilast
UNII-67GXQ6WCC6
4-Methoxy-2-indanamine
1H-Inden-2-amine, 2,3-dihydro-4-methoxy-
GRC3886

Biological Activity

[Description]:

Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.IC50 value:Target: PDE4

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Inflammation/Immunology

[References]

[1]. Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008 Oct;155(3):288-90.

[2]. Study of Oglemilast for the Prevention of Asthma.

[3]. Study To Assess Efficacy and Safety of Oglemilast in Patients With Chronic Obstructive Pulmonary Disease (COPD)

[4]. Study of Oglemilast for the Treatment of Asthma


[Related Small Molecules]

3-Isobutyl-1-methylxanthine | rolipram | PF-04957325 | AN-2728 | GLPG1690 | BAY-60-7550 | Icariin | Ibudilast | PF-8380 | TAK-063 | Dipyridamole | Cilostazol | GSK256066 | Cialis | Pentoxifylline

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
287.8±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H13Cl2F2N3O5S

[ Molecular Weight ]:
516.30

[ Flash Point ]:
136.5±20.6 °C

[ PSA ]:
118.91000

[ LogP ]:
1.66

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.562

[ Storage condition ]:
2-8℃