(20R)-Protopanaxdiol

Names

[ Name ]:
(20R)-Protopanaxdiol

[Synonym ]:
Protopanaxadiol
20R-Betulafolienetriol

Biological Activity

[Description]:

(20R)-Protopanaxadiol is a triterpenoid saponin metabolite of 20(R)-ginsenoside Rg3 in black ginseng. (20R)-Protopanaxadiol exhibits anti-tumor activity and cytotoxicity, and potently inhibits the growth of Helicobacter pylori[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[References]

[1]. Liu L, et al. Enzymatic preparation of 20(S, R)-protopanaxadiol by transformation of 20(S, R)-Rg3 from black ginseng. Phytochemistry. 2010 Sep;71(13):1514-20.

[2]. Bae EA, et al. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull. 2002 Jan;25(1):58-63.

[3]. Hasegawa H, et al. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med. 1994 Jun;60(3):240-3.

Chemical & Physical Properties

[ Density]:
1.036 g/cm3

[ Boiling Point ]:
559.5ºC at 760 mmHg

[ Molecular Formula ]:
C₃₀H₅₂O₃

[ Molecular Weight ]:
460.73200

[ Flash Point ]:
226.1ºC

[ Exact Mass ]:
460.39200

[ PSA ]:
60.69000

[ LogP ]:
6.50060

[ Index of Refraction ]:
1.528

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

An integrated high resolution mass spectrometric data acquisition method for rapid screening of saponins in Panax notoginseng (Sanqi).

J. Pharm. Biomed. Anal. 109 , 184-91, (2015)

The aim of this study was to develop a convenient method without pretreatments for nontarget discovery of interested compounds. The segment and exposure strategy, coupled with two mass spectrometer da...

Integrated evaluation of malonyl ginsenosides, amino acids and polysaccharides in fresh and processed ginseng.

J. Pharm. Biomed. Anal. 107 , 89-97, (2015)

Many analytical methods have been developed to characterize ginsenosides in ginseng. Relatively less attention has been paid to the malonyl ginsenosides, amino acids and polysaccharides in various pro...

TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol.

J. Pharmacol. Sci. 127(1) , 83-91, (2015)

Among important components of American ginseng, protopanaxadiol (PPD) showed more active anticancer potential than other triterpenoid saponins. In this study, we determined the in vivo effects of PPD ...