Zederone

Names

[ Name ]:
Zederone

[Synonym ]:
Oxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one, 1a,3,6,10a-tetrahydro-1a,5,9-trimethyl-
1a,5,9-Trimethyl-1a,3,6,10a-tetrahydrooxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one

Biological Activity

[Description]:

Zederone, a germacrane-type sesquiterpene, has potently cytotoxic against human white blood cancer cells and human prostate cancer cells. Zederone significantly inhibits the proliferation and downregulates the protein expressions of mTOR, and phosphorylated p70 S6 kinase (p-p70s6K) in SKOV3 cells[1][2].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

[Target]

mTOR

[References]

[1]. Prapapan Pimkaew, et al. Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice. Int J Toxicol. 2013 Nov-Dec;32(6):454-62.

[2]. Zhilei Zhang, et al. A study of zederone for the inhibition on ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. J BUON. 2020 Mar-Apr;25(2):785-791.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
365.3±42.0 °C at 760 mmHg

[ Melting Point ]:
153.4-153.9℃ (acetone hexane )

[ Molecular Formula ]:
C₁₅H₁₈O₃

[ Molecular Weight ]:
246.302

[ Flash Point ]:
174.7±27.9 °C

[ Exact Mass ]:
246.125595

[ PSA ]:
42.74000

[ LogP ]:
3.58

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.528

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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