Hycrecrellin A

Names

[ Name ]:
Hycrecrellin A

[Synonym ]:
1-Acetyl-2,5,12-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-2,3-dihydro-1H-cyclohepta[ghi]perylene-6,11-dione
(1S,2R)-1-Acetyl-2,5,12-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-2,3-dihydro-1H-cyclohepta[ghi]perylene-6,11-dione
1H-Cyclohepta[ghi]perylene-6,11-dione, 1-acetyl-2,3-dihydro-2,5,12-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-, (1S,2R)-
1H-Cyclohepta[ghi]perylene-6,11-dione, 1-acetyl-2,3-dihydro-2,5,12-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-
hypocrellin

Biological Activity

[Description]:

Hypocrellin A, a naturally occurring PKC inhibitor, has many biological and pharmacological properties, such as antitumour, antiviral, antibacterial, and antileishmanial activities. Hypocrellin A is a promising photosensitizer for anticancer photodynamic therapy (PDT)[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> TGF-beta/Smad >> PKC

[References]

[1]. Dang L, et al. Effects of hypocrellin A on expression of vascular endothelial growth factor and endothelin-1 in human umbilical endothelial cells. Am J Chin Med. 2007;35(4):713-23.

[2]. Ma YJ, et al. Enhanced Production of Hypocrellin A in Submerged Cultures of Shiraia bambusicola by Red Light. Photochem Photobiol. 2019 May;95(3):812-822.

[3]. Fehr MJ, et al. Roles of oxygen and photoinduced acidification in the light-dependent antiviral activity of hypocrellin A. Biochemistry. 1995 Dec 5;34(48):15845-8.

[4]. Ma G, et al. Antimicrobial and antileishmanial activities of hypocrellins A and B. Antimicrob Agents Chemother. 2004 Nov;48(11):4450-2.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
894.0±65.0 °C at 760 mmHg

[ Melting Point ]:
245-250ºC

[ Molecular Formula ]:
C₃₀H₂₆O₁₀

[ Molecular Weight ]:
546.521

[ Flash Point ]:
299.6±27.8 °C

[ Exact Mass ]:
546.152588

[ PSA ]:
148.82000

[ LogP ]:
3.42

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.737

Safety Information

[ Safety Phrases ]:
22-24/25

Related Compounds

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