Tocopheryl acetate

Names

[ Name ]:
Tocopheryl acetate

[Synonym ]:
(2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl acetate
a-Tocopheryl Acetate
Vitamin E acetate
[2R*(4R*,8R*)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol Acetate
EINECS 231-710-0
Eprolin
Tocopheryl acetate
E-Vimin
Evion
MFCD00072042
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, acetate, (2R)-
Vitamin- E acetate
D-α-Tocopheryl acetate
a-Tocopherol Acetate
TOCOPHEROL ACETATE

Biological Activity

[Description]:

(±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vivo]

(±)-α-Tocopherol acetate ((±)-Vitamin E acetate) (oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15 d, 30 d and 45 d) exhibits significantly high complement activity[1]. (±)-α-Tocopherol acetate (oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15 d, 30 d and 45 d) stimulates the seabream's non-specific immune system after 30 days of administration in the diet (1200 mg/kg)[1]. Animal Model: Gilthead seabream (Sparus aurata L.)[1] Dosage: 600 mg/kg, 1200 mg/kg, 1800 mg/kg Administration: oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15 d,30 d and 45 d Result: Had a positive correlation with serum α-tocopherol levels and the increase being linked to both the dosage and length of use. Showed no enhancement in any of their immune parameters, while those fed the diet supplemented with 1200 mg/kg presented a slightly higher (but not statistically significant) specific growth rate than fish fed the other diets. Enhanced the serum haemolytic activity and the phagocytosis of head-kidney leucocytes by the dietary intake of 1200 mg/kg after 30 and 45 days, although leucocyte migration and respiratory burst activity remained unaffected. Provoked no immunostimulation in 1800 mg/kg.

[References]

[1]. J Ortuño, et al. High dietary intake of alpha-tocopherol acetate enhances the non-specific immune response of gilthead seabream (Sparus aurata L.). Fish Shellfish Immunol. 2000 May;10(4):293-307

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
485.3±0.0 °C at 760 mmHg

[ Melting Point ]:
-28ºC

[ Molecular Formula ]:
C₃₁H₅₂O₃

[ Molecular Weight ]:
472.743

[ Flash Point ]:
235.6±24.7 °C

[ Exact Mass ]:
472.391632

[ PSA ]:
35.53000

[ LogP ]:
12.07

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.488

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GA8747000

CHEMICAL NAME :: 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate

CAS REGISTRY NUMBER :: 7695-91-2

BEILSTEIN REFERENCE NO. :: 0097512

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C31-H52-O3

MOLECULAR WEIGHT :: 472.83

WISWESSER LINE NOTATION :: T66 BOT&J C3Y1&3Y1&3Y1&1 C1 G1 HOV1 I1 J1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 2500 ug/kg

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 25,163,1984

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
GA8747000

[ HS Code ]:
29362800

Customs

[ HS Code ]: 29362800

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Related Compounds

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