loracarbef

Names

[ Name ]:
loracarbef

[Synonym ]:
(6R,7S)-1,3,10-bisabolatriene
5-(1,5-dimethyl-4-hexenyl)-2-methyl-1,3-cyclohexadiene
(-)-(4S,7S)-zingiberene
(6R,7S)-7-[(R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-carboxylic acid
(6R,7S)-zingiberene
(6R,7S)-7-((R)-2-amino-2-phenylacetamido)-3-chloro-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Biological Activity

[Description]:

Loracarbef (Lorabid), a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Loracarbef (Lorabid) demonstrates excellent activity against isolates of Escherichia coli and Klebsiella, Proteus and Salmonella species[2].

[References]

[1]. M Hu, et al. Mechanisms of Transport of Quinapril in Caco-2 Cell Monolayers: Comparison With Cephalexin. Pharm Res. 1995 Aug;12(8):1120-5.

[2]. J W Dyke, et al. Antimicrobial Activity of New Antibiotics Against Bacterial Isolates From a Community Hospital. Chemotherapy. Sep-Oct 1993;39(5):315-21.

Chemical & Physical Properties

[ Density]:
1.52g/cm3

[ Boiling Point ]:
662.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₆ClN₃O₄

[ Molecular Weight ]:
349.76900

[ Flash Point ]:
354.3ºC

[ Exact Mass ]:
349.08300

[ PSA ]:
112.73000

[ LogP ]:
1.73990

[ Index of Refraction ]:
1.677

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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