Colchicine, 10-(benzylamino)-10-demethoxy-
Names
[ CAS No. ]:
76129-15-2
[ Name ]:
Colchicine, 10-(benzylamino)-10-demethoxy-
[Synonym ]:
N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-benzylamino-9-oxobenzo[a]heptalen-7-yl]acetamide
N-<5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-<(phenylmethyl)amino>benzo<a>heptalen-7-yl>-(S)-acetamide
10-(Benzylamino)-10-demethoxycolchicine
N-((S)-10-Benzylamino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid
(S)-7-Acetylamino-10-benzylamino-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on
N-((S)-10-benzylamino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-9-oxo-10-benzylaminobenzo[a]heptalen-7-yl]acetamide
Chemical & Physical Properties
[ Density]:
1.25g/cm3
[ Boiling Point ]:
794.2ºC at 760 mmHg
[ Molecular Formula ]:
C28H30N2O5
[ Molecular Weight ]:
474.54800
[ Flash Point ]:
434.1ºC
[ Exact Mass ]:
474.21500
[ PSA ]:
85.89000
[ LogP ]:
4.93900
[ Index of Refraction ]:
1.622
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AC8755000
- CHEMICAL NAME :
- Acetamide, N-(5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-((phe nylmethyl)amino)benzo (a) heptalen-7-yl)-, (S)-
- CAS REGISTRY NUMBER :
- 76129-15-2
- BEILSTEIN REFERENCE NO. :
- 3185612
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C28-H30-N2-O5
- MOLECULAR WEIGHT :
- 474.60
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 DO1 JMV1 NM1R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981