ARTOCARPIN

Names

[ Name ]:
ARTOCARPIN

[Synonym ]:
2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(1E)-3-methylbut-1-en-1-yl]-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
Norartocarpin
ARTOCARPIN
2-(2,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methyl-1-butenyl)-3-(3-methyl-2-butenyl)-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-3,6-bis(3-methyl-2-buten-1-yl)-
2-(2,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-3,6-bis(3-methyl-2-buten-1-yl)-4H-chromen-4-one
2-(2,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(1E)-3-methyl-1-buten-1-yl]-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(1E)-3-methyl-1-buten-1-yl]-3-(3-methyl-2-buten-1-yl)-
Kuwanon C

Biological Activity

[Description]:

Artocarpin is an isoprenoid-substituted flavonoid, that can be isolated from the wood of Artocarpus heterophyllus. Artocarpin inhibits melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. The presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Arung ET, et al. Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis. Planta Med. 2006 Jul;72(9):847-50.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
651.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₈O₆

[ Molecular Weight ]:
436.50

[ Flash Point ]:
219.9±25.0 °C

[ Exact Mass ]:
436.188599

[ PSA ]:
100.13000

[ LogP ]:
6.35

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.614

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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