6-Methoxytricin

Names

[ CAS No. ]:
76015-42-4

[ Name ]:
6-Methoxytricin

[Synonym ]:
5,7-Dihydroxy-2-(4-hydroxy-3,5-dimethoxy-phenyl)-6-methoxy-chromen-4-one
6-methoxytricin
6,3',5'-trimethoxyapigenin

Biological Activity

[Description]:

6-Methoxytricin (Compound 6) is an flavonoid isolated from Artemisia iwayomogi. 6-Methoxytricin (Compound 6) is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities with IC50 values of 30.29 μM and 134.88 μM, respectively. 6-Methoxytricin (Compound 6) has potential as an anti-diabetic complications agent[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase
Research Areas >> Metabolic Disease

[Target]

IC50: 30.29 μM (AR); 134.88 μM (AGE) (6-​Methoxytricin)[1]


[References]

[1]. Lee YK, et al. Inhibitory Effect of Chemical Constituents Isolated from Artemisia iwayomogi on Polyol Pathway and Simultaneous Quantification of Major Bioactive Compounds. Biomed Res Int. 2017;2017:7375615.

Chemical & Physical Properties

[ Boiling Point ]:
641.7±55.0 °C

[ Melting Point ]:
238-240 °C

[ Molecular Formula ]:
C18H16O8

[ Molecular Weight ]:
360.31500

[ Exact Mass ]:
360.08500

[ PSA ]:
118.59000

[ LogP ]:
2.60260

Related Compounds