norastemizole

Names

[ Name ]:
norastemizole

[Synonym ]:
T 1348
Tetemizole
Soltara
Norastemizole

Biological Activity

[Description]:

Tecastemizole (Norastemizole), a major metabolite of Astemizole, is a potent and selective H1 receptor antagonist. Tecastemizole shows anti-inflammatory activities[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Lever R, et al. Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. Clin Exp Allergy. 2007 Jun;37(6):909-17.

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
519.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₁FN₄

[ Molecular Weight ]:
324.40

[ Flash Point ]:
268.2ºC

[ Exact Mass ]:
324.17500

[ PSA ]:
45.11000

[ LogP ]:
3.13830

[ Index of Refraction ]:
1.658

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.