Imanixil

Names

[ Name ]:
Imanixil

Biological Activity

[Description]:

Imanixil (HOE-402 free base) is an inducer of the LDL receptor (LDLR). Imanixil (HOE-402 free base) is also a potent cholesterol-lowering compound, which inhibits very low density-lipoprotein (VLDL) production, and consequently attenuates atherosclerosis development[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[References]

[1]. Draijer R, et al. HOE 402 lowers serum cholesterol levels by reducing VLDL-lipid production, and not by induction of the LDL receptor, and reduces atherosclerosis in wild-type and LDL receptor-deficient mice. Biochem Pharmacol. 2002 May 1;63(9):1755-61.

Chemical & Physical Properties

[ Density]:
1.428g/cm3

[ Molecular Formula ]:
C₁₇H₁₇F₃N₆O₂

[ Molecular Weight ]:
394.35100

[ Exact Mass ]:
394.13700

[ PSA ]:
113.24000

[ LogP ]:
3.68610

[ Index of Refraction ]:
1.601

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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