Argpressin acetate

Names

[ Name ]:
Argpressin acetate

[Synonym ]:
Arginine Vasopressin Diacetate

Biological Activity

[Description]:

Arginine vasopressin (AVP, also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. AVP can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). AVP also have potentially important effects on centrally regulated metabolic processes[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[In Vitro]

AVP induces proliferation and prevented cytokine-induced apoptosis in rodent and human beta-cells[1]. Cell Proliferation Assay[1] Cell Line: clonal BRIN BD11 and 1.1B4 cells Concentration: 10-6 M Incubation Time: 2 h Result: Increased proliferation of rodent and human beta-cells. Apoptosis Analysis[1] Cell Line: clonal BRIN BD11 and 1.1B4 cells Concentration: 10-6 M Incubation Time: 2 h Result: Protected against cytokine-induced beta-cell apoptosis.

[In Vivo]

AVP (25 nmol/kg bw; intraperitoneal injection; once) significantly reduces overall AUC glucose values，but not increases insulin levels in mice[1]. Animal Model: NIH Swiss mice (adult; male; 12-14weeks) [1] Dosage: 25 nmol/kg bw Administration: AVP (25 nmol/kg bw; intraperitoneal injection; once) Result: Reduced (P<0.001) overall AUC glucose values，but not increased insulin levels in mice.

[References]

[1]. Shruti Mohan, et al. Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival. Biochimie

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₈H₆₉N₁₅O₁₄S₂

[ Molecular Weight ]:
1144.28000

[ Exact Mass ]:
1143.46000

[ PSA ]:
549.33000

[ LogP ]:
1.25190

Related Compounds

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