Methyl L-tryptophanate hydrochloride

Names

[ Name ]:
Methyl L-tryptophanate hydrochloride

[Synonym ]:
L-Tryptophan methyl ester hydrochloride
EINECS 231-385-5
MFCD00066134
methyl (2S)-2-amino-3-(1H-indol-3-yl)propanoate hydrochloride
Methyl L-tryptophanate hydrochloride (1:1)
methyl (2S)-2-amino-3-(1H-indol-3-yl)propanoate,hydrochloride
D-Tryptophan methyl ester hydrochloride
H-Trp-OMe·HCl
L-Tryptophanmethylesterhydrochloridesalt
Methyl L-tryptophanate hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
390.6ºC at 760 mmHg

[ Melting Point ]:
218-220ºC

[ Molecular Formula ]:
C₁₂H₁₅ClN₂O₂

[ Molecular Weight ]:
254.713

[ Flash Point ]:
190ºC

[ Exact Mass ]:
254.082199

[ PSA ]:
68.11000

[ LogP ]:
2.71300

[ Index of Refraction ]:
19.5 ° (C=5， MeOH)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.

Infect. Immun. 79 , 4425-4437, (2011)

Gamma interferon (IFN-γ) induces expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial cells, the permissive cells for the obligate intracellular bact...

Clinical significance of tryptophan metabolism in the nontumoral hemisphere in patients with malignant glioma.

J. Nucl. Med. 55(10) , 1605-10, (2014)

α-(11)C-methyl-L-tryptophan (AMT) PET allows evaluation of brain serotonin synthesis and can also track upregulation of the immunosuppressive kynurenine pathway in tumor tissue. Increased AMT uptake i...

Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Nat. Chem. Biol. 5 , 45-52, (2009)

Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting tr...