LOVASTATIN HYDROXY ACID, SODIUM SALT
Names
[ CAS No. ]:
75225-51-3
[ Name ]:
LOVASTATIN HYDROXY ACID, SODIUM SALT
[Synonym ]:
2-methoxy-4,4'-dihydroxychalcone
Echinantin
4',4-dihydroxy-2-methoxychalcone
LOVASTATIN HYDROXY ACID, SODIUM SALT
Echinatin
Mevinolinic acid
lovastatin acid
loureirin C
lovastatin hydroxy acid
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Ki: 0.6 nM (HMG-CoA reductase)[1]
[References]
Chemical & Physical Properties
[ Density]:
1.14g/cm3
[ Boiling Point ]:
602.3ºC at 760 mmHg
[ Molecular Formula ]:
C24H38O6
[ Molecular Weight ]:
422.55
[ Flash Point ]:
199.1ºC
[ Exact Mass ]:
447.26800
[ PSA ]:
106.89000
[ LogP ]:
2.38090
[ Index of Refraction ]:
1.537
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QJ7180000
- CHEMICAL NAME :
- 1-Naphthaleneheptanoic aicd, 1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimet hyl-8- (2-methyl-1-oxobutoxy)-, ammonium salt, (1S-(1-alpha(beta-S*,delta-S*),2-alpha,6-beta, 8-beta(R*),8a-beta))-
- CAS REGISTRY NUMBER :
- 75225-51-3
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C24-H38-O6.H3-N
- MOLECULAR WEIGHT :
- 439.66
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 749 mg/kg
- SEX/DURATION :
- female 6-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 28,449,1983