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Lovastatin hydroxy acid sodium

Names

[ CAS No. ]:
75225-50-2

[ Name ]:
Lovastatin hydroxy acid sodium

[Synonym ]:
MB 530B
sodium mevinolinate
lovastatin acid sodium salt
lovastatinic sodium salt
pravastatin
lovastatin hydroxy acid sodium salt
Sodium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]-3,5-dihydroxyheptanoate
sodium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
[1S-[1a(bS,dS),2a,6b,8b(R),8aa]]-1,2,6,7,8,8a-Hexahydro-b,d-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid monosodium salt
1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-8-[(2S)-2-methyl-1-oxobutoxy]-, sodium salt, (βR,δR,1S,2S,6R,8S,8aR)- (1:1)
lovastatin Na
Lovastatin Hydroxy Acid
LOVASTATIN SODIUM
mevinolin sodium salt
Lovastatin Impurity 2

Biological Activity

[Description]:

Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
Research Areas >> Metabolic Disease

[Target]

Ki: 0.6 nM (HMG-CoA reductase)[1]


[In Vitro]

Mevinolin in the hydroxy-acid form, mevinolinic acid, is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [mevalonate: NADP+ oxidoreductase (CoA-acylating)][1].

[References]

[1]. A W Alberts, eta al. Mevinolin: A Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme A Reductase and a Cholesterol-Lowering Agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.

Chemical & Physical Properties

[ Boiling Point ]:
602.3ºC at 760 mmHg

[ Melting Point ]:
154-160ºC

[ Molecular Formula ]:
C24H37NaO6

[ Molecular Weight ]:
444.537

[ Flash Point ]:
199.1ºC

[ Exact Mass ]:
444.248779

[ PSA ]:
106.89000

[ LogP ]:
2.38090

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds