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Fludarabine triphosphate

Names

[ CAS No. ]:
74832-57-8

[ Name ]:
Fludarabine triphosphate

Biological Activity

[Description]:

Fludarabine triphosphate (F-ara-ATP), the cytotoxic metabolite of Fludarabine phosphate (HY-B0028), inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[References]

[1]. Erica L. Woodahl, et al. A NOVEL PHENOTYPIC METHOD TO DETERMINE FLUDARABINE TRIPHOSPHATE ACCUMULATION IN T-LYMPHOCYTES FROM HEMATOPOIETIC CELL TRANSPLANTATION PATIENTS. J Cell Mol Med. 2020 Jul 31.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H15FN5O13P3

[ Molecular Weight ]:
525.17

Related Compounds