Geclosporin
Names
[ CAS No. ]:
74436-00-3
[ Name ]:
Geclosporin
[Synonym ]:
Cyclo(((2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl)
cyclosporin G
(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Nva-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
Cyclosporin A,7-L-norvaline
Cyclosporin Impurity 7
Chemical & Physical Properties
[ Density]:
1.013g/cm3
[ Boiling Point ]:
1297.8ºC at 760 mmHg
[ Molecular Formula ]:
C63H113N11O12
[ Molecular Weight ]:
1216.64000
[ Flash Point ]:
738.7ºC
[ Exact Mass ]:
1215.86000
[ PSA ]:
278.80000
[ LogP ]:
4.53960
[ Index of Refraction ]:
1.467
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GZ4130000
- CHEMICAL NAME :
- Cyclosporin A, 7-L-norvaline-
- CAS REGISTRY NUMBER :
- 74436-00-3
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C63-H113-N11-O12
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 420 mg/kg/28D-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal - other changes
- REFERENCE :
- TRPLAU Transplantation. (Williams & Wilkins, Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1963- Volume(issue)/page/year: 57,1231,1994