Stromatoxin 1

Names

[ CAS No. ]:
741738-59-0

[ Name ]:
Stromatoxin 1

Biological Activity

[Description]:

Stromatoxin 1 is an inhibitor of Potassium Channel, a peptide which can be isolated from tarantulas. Stromatoxin 1 selectively inhibits K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3 channels. K(V)2.1 and K(V)2.2, but not K(V)4.2, channel subunits play a key role in opposing both myogenic and neurogenic urinary bladder smooth muscle (UBSM) contractions in rats[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3[1]


[References]

[1]. Chen M, et al. Voltage-gated K(+) channels sensitive to stromatoxin-1 regulate myogenic and neurogenic contractions of rat urinary bladder smooth muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Jul;299(1):R177-84.  

Chemical & Physical Properties

[ Molecular Formula ]:
C156H237N49O48S7

[ Molecular Weight ]:
3791.31

Related Compounds

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