Beta-Hydroxyisovalerylshikonin

Names

[ Name ]:
Beta-Hydroxyisovalerylshikonin

Biological Activity

[Description]:

Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermium radix, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

[Target]

IC50: 0.7 μM (EGFR), 1 μM (v-Src)[1]

[References]

[1]. Hashimoto S, et al. Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases. Jpn J Cancer Res. 2002 Aug;93(8):944-51.

Chemical & Physical Properties

[ Density]:
1.312g/cm3

[ Boiling Point ]:
616.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₄O₇

[ Molecular Weight ]:
388.41100

[ Flash Point ]:
215.8ºC

[ Exact Mass ]:
388.15200

[ PSA ]:
121.13000

[ LogP ]:
2.83230

[ Index of Refraction ]:
1.596

Related Compounds

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