7415-78-3

7415-78-3 structure

Name: Beta-Hydroxyisovalerylshikonin
Chemical Name: β-HYDROXYISOVALERYLSHIKONIN
CAS Number: 7415-78-3
Molecular Formula: C₂₁H₂₄O₇
Molecular Weight: 388.41100
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2016-05-04 18:32:26
Modify Date: 2024-01-11 19:14:50
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermium radix, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells[1].

Name	β-HYDROXYISOVALERYLSHIKONIN

Description	Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermium radix, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src
Target	IC50: 0.7 μM (EGFR), 1 μM (v-Src)[1]
References	[1]. Hashimoto S, et al. Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases. Jpn J Cancer Res. 2002 Aug;93(8):944-51.