Imiclopazine

Names

[ Name ]:
Imiclopazine

[Synonym ]:
Chlorimpiphenine dihydrochloride
Chorimpiphenine
P-4241
Chlorimiphene dichloride
Ponsital
Imiclopazine hydrochloride
Chlorimphenine hydrochloride
Imiclopazine dihydrochloride
Asta p 4241

Biological Activity

[Description]:

Imiclopazine is a phenothiazine derivative with good sedative, analgesic, antiaggressive and antiemetic effects[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Imiclopazine shows multidrug-resistance (MDR)-reversal activity in P388 and P388/ADR cells, with EC50 values of both 200 μM[2].

[References]

[1]. A Ramu, et al. Reversal of multidrug resistance by phenothiazines and structurally related compounds. Cancer Chemother Pharmacol. 1992;30(3):165-73.

[2]. D. Lenke, et al. Pharmacological activity of new phenothiazine and azaphenothiazine derivatives. January 1971, Arzneimittel-Forschung. 21:288-293.

Chemical & Physical Properties

[ Density]:
1.252g/cm3

[ Boiling Point ]:
659.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₅H₃₂ClN₅OS

[ Molecular Weight ]:
486.07200

[ Flash Point ]:
352.8ºC

[ Exact Mass ]:
485.20200

[ PSA ]:
58.57000

[ LogP ]:
4.13440

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ0621400

CHEMICAL NAME :: 2-Imidazolidinone, 1-(2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-pipe razinyl)ethyl)-3- methyl-, dihydrochloride

CAS REGISTRY NUMBER :: 7414-95-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C25-H32-Cl-N5-O-S.2Cl-H

MOLECULAR WEIGHT :: 559.05

WISWESSER LINE NOTATION :: T C666 BN ISJ EG B3- AT6N DNTJ D2- AT5NVNTJ C1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 321 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 68 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.