4-Hydroxyphenyl-dimethyl-phenylsilan

Names

[ CAS No. ]:
74027-99-9

[ Name ]:
4-Hydroxyphenyl-dimethyl-phenylsilan

[Synonym ]:
4-phenyldimethylsilylphenole

Biological Activity

[Description]:

Estrogen receptor-IN-1 (compound 16) is a potent estrogen receptor (ER) inhibitor with IC50s of 13, 5µM for ERα and Erβ, respectively[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR
Research Areas >> Metabolic Disease

[Target]

ERα:13 μM (IC50)

ERβ:5 μM (IC50)


[References]

[1]. Saito H, et al. Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives. Bioorg Med Chem. 2020 Feb 15;28(4):115310.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H16OSi

[ Molecular Weight ]:
228.36200

[ Exact Mass ]:
228.09700

[ PSA ]:
20.23000

[ LogP ]:
2.21480

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.