2-demethylcolchicine
Names
[ CAS No. ]:
7336-36-9
[ Name ]:
2-demethylcolchicine
[Synonym ]:
O2-Demethylcolchicin
2-O-demethylcolchicine
3-demethylcolchicine
Chemical & Physical Properties
[ Density]:
1.31g/cm3
[ Boiling Point ]:
766.1ºC at 760mmHg
[ Molecular Formula ]:
C21H23NO6
[ Molecular Weight ]:
385.41000
[ Flash Point ]:
417.1ºC
[ Exact Mass ]:
385.15300
[ PSA ]:
94.09000
[ LogP ]:
2.95950
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0880000
- CHEMICAL NAME :
- Colchicine, O(sup 2)-demethyl-
- CAS REGISTRY NUMBER :
- 7336-36-9
- LAST UPDATED :
- 199409
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C21-H23-N-O6
- MOLECULAR WEIGHT :
- 385.45
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 75 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 19 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,453,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 16 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 16577 ug/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Related Compounds
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.