Glycerol-d8

Names

[ CAS No. ]:
7325-17-9

[ Name ]:
Glycerol-d8

[Synonym ]:
MFCD00084149
1,2,3-Propanetriol-d8
Glycerol-d8
Glycerin-d8
Deuterated glycerol

Biological Activity

[Description]:

Glycerol-d8 is the deuterium labeled Glycerol[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Chemical & Physical Properties

[ Density]:
1.371 g/mL at 25ºC

[ Boiling Point ]:
182ºC(lit.)

[ Melting Point ]:
20ºC(lit.)

[ Molecular Formula ]:
C₃D₈O₃

[ Molecular Weight ]:
100.14300

[ Flash Point ]:
>230 °F(lit.)

[ Exact Mass ]:
100.09800

[ PSA ]:
60.69000

[ Index of Refraction ]:
n20/D 1.466(lit.)

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase.

Eur. J. Pharm. Sci. 77 , 180-8, (2015)

In mammalian brain, monoacylglycerol lipase (MAGL) is the primary enzyme responsible for terminating signaling function of the endocannabinoid 2-arachidonoylglycerol (2-AG). Previous in vivo studies w...

Molecular-Level Insight into the Differential Oxidase and Oxygenase Reactivities of de Novo Due Ferri Proteins.

J. Am. Chem. Soc. 137 , 9302-14, (2015)

Using the single-chain due ferri (DFsc) peptide scaffold, the differential oxidase and oxygenase reactivities of two 4A→4G variants, one with two histidines at the diiron center (G4DFsc) and the other...

Distribution of bioactive lipid mediators in human skin.

J. Invest. Dermatol. 135 , 1510-20, (2015)

The skin produces bioactive lipids that participate in physiological and pathological states, including homeostasis, induction, propagation, and resolution of inflammation. However, comprehension of t...