sulfamoxol

Names

[ CAS No. ]:
729-99-7

[ Name ]:
sulfamoxol

[Synonym ]:
SULFAMOXOLE
Sulfamoxol
4-amino-N-(4,5-dimethyl-1,3-oxazol-2-yl)benzenesulfonamide
Sulphamoxole
Sulfavigor
sulphamoxazole
Oxasulfa
Sulfmidil
Sulfadimethyloxazole
Sulfamoxolum
Justamil
sulfisoxazole
Sulfuno

Biological Activity

[Description]:

Sulfamoxole is a broad- spectrum chemotherapeutic antimicrobial agent. Sulfamoxole can be used for the study of pediatric infections[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. F Lagler, R Kretzschmar, et al. Toxicological Investigations of the Combination Sulfamoxole/Trimethoprim, a New Broad-Spectrum Chemotherapeutic. Arzneimittelforschung. 1976;26(42):634-43.

[2]. J A DUGGER, et al. Sulfamoxole (Nuprin), a New Sulfonamide, in Pediatric Practice. J New Drugs. Sep-Oct 1961;1:223-9.

Chemical & Physical Properties

[ Density]:
1.411g/cm3

[ Boiling Point ]:
481ºC at 760 mmHg

[ Melting Point ]:
197-199℃

[ Molecular Formula ]:
C₁₁H₁₃N₃O₃S

[ Molecular Weight ]:
267.30400

[ Flash Point ]:
244.7ºC

[ Exact Mass ]:
267.06800

[ PSA ]:
106.60000

[ LogP ]:
3.40940

[ Index of Refraction ]:
1.626

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WO9150000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(4,5-dimethyl-2-oxazolyl)-

CAS REGISTRY NUMBER :: 729-99-7

LAST UPDATED :: 199706

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H13-N3-O3-S

MOLECULAR WEIGHT :: 267.33

WISWESSER LINE NOTATION :: T5N COJ BMSWR DZ& D1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >12500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,634,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,634,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,612,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,634,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1285 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,612,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,612,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1525 mg/kg/9W-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Endocrine - changes in pituitary weight Endocrine - changes in thyroid weight

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,617,1960

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
43

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
WO9150000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Adverse reactions to sulphonamide and sulphonamide-trimethoprim antimicrobials: clinical syndromes and pathogenesis.

Adverse Drug React. Toxicol. Rev. 15(1) , 9-50, (1996)

Combination of trimethoprim with sulfonamides other than sulfamethoxazole.

Rev. Infect. Dis. 4(2) , 411-8, (1982)

Early in the development of trimethoprim (TMP), the response to the drug was less than enthusiastic. Preliminary clinical trials were performed with sulfonamides that were unsuitable partners. On the ...

Use of p-benzoquinone for the spectrophotometric determination of certain sulphonamides.

J. Pharm. Biomed. Anal. 9(7) , 531-8, (1991)

A simple spectrophotometric method for the determination of 15 sulphonamides in bulk and in dosage forms is described. The method is based on the interaction of p-benzoquinone with sulphonamides in 0....