METHICILLIN SODIUM (500 MG) (AS)

Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin sodium hydrate is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins. Methicillin sodium hydrate can be used for the research of skin infections, osteomyelitis, and endocarditis[1].

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

Methcillin sodium hydrate (20 μg/mL, 24 h) results in a rapid decrease in CFU of S. aureus[2].

Methicillin sodium hydrate (Intramuscular administration, 40 mg/kg every 6 h, 5 days), in S. aureus.-infected rabbits[2].

[1]. Sharon S. Castle. Methicillin. xPharm: The Comprehensive Pharmacology Reference 2007, Pages 1-4.

[2]. Jaime Carrizosa, et al. Treatment of Experimental Staphylococcus aureus Endocarditis: Comparison of Cephalothin, Cefazolin, and Methicillin. Antimicrob Agents Chemother. 1978 Jan; 13(1): 74–77.