4-thiothymidine

Names

[ Name ]:
4-thiothymidine

[Synonym ]:
deoxy-4-thiothymidine
4-thio-thymidine
4-Thio-thymidin
2(1H)-Pyrimidinone, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-3,4-dihydro-5-methyl-4-thioxo-
4-thiothymidine
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-methyl-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone

Biological Activity

[Description]:

4-Thiothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₀H₁₄N₂O₄S

[ Molecular Weight ]:
258.29

[ Exact Mass ]:
258.067413

[ PSA ]:
119.57000

[ LogP ]:
-0.07

[ Index of Refraction ]:
1.672

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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