9-Anthracenecarboxylic acid

Names

[ CAS No. ]:
723-62-6

[ Name ]:
9-Anthracenecarboxylic acid

[Synonym ]:
9-Anthroic acid
EINECS 211-964-9
9-Carboxyanthracene
ANCA
anthracene-9-carboxylic acid
MFCD00001257
9-Anthracene carboxylic acid
anthracenecarboxylic acid
9-Anthracenecarboxylic acid
Polyoxyethylenesorbitan monolaurate

Biological Activity

[Description]:

Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel

Research Areas >> Others

[Target]

Ca2+-activated Cl- currents[1]

[In Vitro]

Anthracene-9-carboxylic acid causes a voltage-dependent block of outward currents in HEK 293T cells and inhibits a larger fraction of the current as depolarization increased[1]. Anthracene-9-carboxylic acid induces a strong potentiation of tail currents measured at -100 mV after depolarizing voltages, as well as a prolongation of the deactivation kinetics in HEK 293T[1]. Anthracene-9-carboxylic acid (500 μM, rabbit pulmonary artery smooth muscle cells) produces a small inhibition of the maximum outward Cl- current at +70 mV (21±10%) but augmented the amplitude of the instantaneous inward relaxation at -80 mV by 321±34%[2].

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
467.5±14.0 °C at 760 mmHg

[ Melting Point ]:
213-217 °C(lit.)

[ Molecular Formula ]:
C₁₅H₁₀O₂

[ Molecular Weight ]:
222.239

[ Flash Point ]:
206.1±14.8 °C

[ Exact Mass ]:
222.068085

[ PSA ]:
37.30000

[ LogP ]:
4.36

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.743

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB8764000

CHEMICAL NAME :: 9-Anthroic acid

CAS REGISTRY NUMBER :: 723-62-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H10-O2

MOLECULAR WEIGHT :: 222.25

WISWESSER LINE NOTATION :: L C666J BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Behavioral - rigidity (including catalepsy) Behavioral - muscle contraction or spasticity

MUTATION DATA

TYPE OF TEST :: Phage inhibition capacity

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 127 ug/well

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,349,1991

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CB8764000

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats.

Mol. Pain 11 , 41, (2015)

Calcium-activated chloride channels (CaCCs) activation induces membrane depolarization by increasing chloride efflux in primary sensory neurons that can facilitate action potential generation. Previou...

Integrated microfluidic chip and online SCX separation allows untargeted nanoscale metabolomic and peptidomic profiling.

J. Proteome Res. 14(3) , 1621-6, (2015)

Metabolomics and peptidomics are systems biology approaches in which broad populations of molecular species produced in a cell or tissue sample are identified and quantified. These two molecular popul...

Extracellular magnesium and calcium reduce myotonia in isolated ClC-1 chloride channel-inhibited human muscle.

Muscle Nerve 51(1) , 65-71, (2015)

Experimental myotonia induced in rat muscle by ClC-1 chloride channel-inhibited has been shown to be related inversely to extracellular concentrations of Mg(2+) and Ca(2+) ([Mg(2+) ]o and [Ca(2+) ]o) ...