5-Hydroxymethyl-2’-deoxycytidine

Names

[ Name ]:
5-Hydroxymethyl-2’-deoxycytidine

[Synonym ]:
5-hydroxymethyl-2,4-dimethyl-pyrrole-3-carboxylic acid ethyl ester
5-(Hydroxymethyl)-2'-deoxycytidine
5-Hydroxymethyl-2,4-dimethyl-pyrrol-3-carbonsaeure-aethylester
5-Hydroxymethyl-2,4-dimethyl-3-pyrrolcarbonsaeure-ethylester

Biological Activity

[Description]:

5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Ewelina Zarakowska, et al. Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1003-1009.

[2]. Shuo Liu, et al. Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 2013 Jul;41(13):6421-9.

Chemical & Physical Properties

[ Melting Point ]:
205 °C

[ Molecular Formula ]:
C₁₀H₁₆N₃O₈P

[ Molecular Weight ]:
337.22300

[ Exact Mass ]:
337.06800

[ PSA ]:
187.17000

5-Hydroxymethyl-2’-deoxycytidine

Names

Biological Activity

Chemical & Physical Properties

MSDS

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Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds