Mastoparan X

Names

[ CAS No. ]:
72093-22-2

[ Name ]:
Mastoparan X

[Synonym ]:
DL-AP5 Sodium salt
H-ILE-ASN-TRP-LYS-GLY-ILE-ALA-ALA-MET-ALA-LYS-LYS-LEU-LEU-NH2
INWKGIAAMAKKLL-NH2
Ile-Asn-Trp-Lys-Gly-Ile-Ala-Ala-Met-Ala-Lys-Lys-Leu-Leu-NH2

Biological Activity

[Description]:

Mastoparan X is a GTP-binding regulatory protein (G protein)-activating peptide, and a tetradecapeptide from wasp venom. Mastoparan X acts function by the direct activation of G protein that couple to phospholipase C to cause secretion from various kinds of cells[1].

[Related Catalog]:

Research Areas >> Others

[Target]

GTP-binding regulatory protein (G protein)[1]

[In Vitro]

Mastoparan X (1.5 mM) interacts with phospholipid bicelles, and results the line broadening[2]. Mastoparan X binds to the membrane, and increases the cell’s permeability to cations leading to a disruption in the electrolyte balance and cell lysis[2].

[References]

[1]. Wakamatsu K, et al. Membrane-bound conformation of mastoparan-X, a G-protein-activating peptide. Biochemistry. 1992 Jun 23;31(24):5654-60.

[2]. Whiles JA, et al. Orientation and effects of mastoparan X on phospholipid bicelles. Biophys J. 2001 Jan;80(1):280-93.

Chemical & Physical Properties

[ Density]:
1.207 g/cm3

[ Boiling Point ]:
1797.4ºC at 760 mmHg

[ Molecular Formula ]:
C₇₃H₁₂₆N₂₀O₁₅S

[ Molecular Weight ]:
1555.97000

[ Flash Point ]:
1040.8ºC

[ Exact Mass ]:
1554.94000

[ PSA ]:
609.65000

[ LogP ]:
6.99990

[ Index of Refraction ]:
1.558

Safety Information

[ Safety Phrases ]:
22-24/25

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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