5(6)-Carboxyfluorescein

Names

[ CAS No. ]:
72088-94-9

[ Name ]:
5(6)-Carboxyfluorescein

[Synonym ]:
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 3',6'-dihydroxy-3-oxo-, compd. with 3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid (1:1)
3',6'-Dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid - 3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid (1:1)
MFCD00151081
Fluoresceincarboxylic Acid
EINECS 276-331-1

Biological Activity

[Description]:

5(6)-Carboxyfluorescein contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid; cell-impermeant 5,6-FAM can also be used as a nonfixable polar tracer to investigate fusion, lysis and gap-junctional communication and to detect changes in cell or liposome volume.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Dye Reagents

Research Areas >> Others

[References]

[1]. Babcock DF. Examination of the intracellular ionic environment and of ionophore action by null point measurements employing the fluorescein chromophore. J Biol Chem. 1983 May 25;258(10):6380-9.

[2]. Bonizzoni M, et al. PAMAM dendrimer-induced aggregation of 5(6)-carboxyfluorescein. J Org Chem. 2012 Feb 3;77(3):1258-66.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
275 °C

[ Molecular Formula ]:
C₂₁H₁₂O₇

[ Molecular Weight ]:
376.32

[ PSA ]:
226.58000

[ LogP ]:
6.72800

[ Storage condition ]:
Store at 2-8

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
37/39-26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
CQ7700000

[ HS Code ]:
29335995

Customs

[ HS Code ]: 29335995

Articles

Characteristics and photo-responsive release property of liposome containing 7-acetoxy coumarin.

J. Nanosci. Nanotechnol. 11 , 10262-10270, (2011)

A photo-responsive liposome was developed by loading 7-acetoxy coumarin (ATC) in egg phosphatidylcholine (EPC) liposome. ATC was derivetized from 7-hydroxy coumarin using sodium acetate. The ATC-loade...

A novel assay for detecting fusion pore formation: implications for the fusion mechanism.

Biochemistry 52(47) , 8510-7, (2013)

Membrane fusion is broadly envisioned as a two- or three-step process proceeding from contacting bilayers through one or two semistable, nonlamellar lipidic intermediate structures to a fusion pore. A...

Development of novel diolein-niosomes for cutaneous delivery of tretinoin: influence of formulation and in vitro assessment.

Int. J. Pharm. 477(1-2) , 176-86, (2014)

This work describes innovative niosomes, composed of diolein alone or in association with the hydrophilic penetration enhancer Labrasol(®), as carriers for cutaneous drug delivery. The model drug was ...

Related Compounds

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