Ph-PEG3

Names

[ Name ]:
Ph-PEG3

[Synonym ]:
2-(2-Hydroxy-aethoxy)-1-(2-phenoxy-aethoxy)-aethan
[2-(2-Hydroxy-aethoxy)-aethyl]-(2-phenoxy-aethyl)-aether
2-[2-(2-phenoxy-ethoxy)-ethoxy]-ethanol
8-phenoxy-3,6-dioxa-1-octanol
2-[2-(2-phenoxyethoxy)ethoxy]ethan-1-ol
Ethanol,2-[2-(2-phenoxyethoxy)ethoxy]
triethylene glycol phenyl ether
2-[2-(2-Phenoxy-aethoxy)-aethoxy]-aethanol
bis[2-(2-hydroxyethoxy)ethoxy]benzene
TRIETHYLENE GLYCOL MONOPHENYL ETHER

Biological Activity

[Description]:

Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.097g/cm3

[ Boiling Point ]:
351.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₈O₄

[ Molecular Weight ]:
226.26900

[ Flash Point ]:
166.6ºC

[ Exact Mass ]:
226.12100

[ PSA ]:
47.92000

[ LogP ]:
1.09090

[ Index of Refraction ]:
1.504

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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