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Ald-Ph-amido-PEG3-C2-NH2

Names

[ CAS No. ]:
1404111-56-3

[ Name ]:
Ald-Ph-amido-PEG3-C2-NH2

[Synonym ]:
ALD-PH-NH-PEG3-NH2

Biological Activity

[Description]:

Ald-Ph-amido-PEG3-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
542.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H24N2O5

[ Molecular Weight ]:
324.372

[ Flash Point ]:
282.1±30.1 °C

[ Exact Mass ]:
324.168518

[ LogP ]:
-0.57

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.540

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds