Suc-Ala-Ala-Phe-AMC

Names

[ CAS No. ]:
71973-79-0

[ Name ]:
Suc-Ala-Ala-Phe-AMC

[Synonym ]:
AMC084
Suc-AAF-AMC
N-Succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin
Suc-Ala-Ala-Phe-AMC
Suc-Ala-Ala-Phe-7-Amino-4-Methylcoumarin
MFCD00038448

Biological Activity

[Description]:

Suc-Ala-Ala-Phe-AMC is a fluorogenic chymotrypsin substrate, can be hydrolyzed by endopeptidase. Suc-Ala-Ala-Phe-AMC has been used in both in vivo assays of the acrosome reaction and in vitro enzyme assays[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Farach HA Jr, et al. Evidence for the involvement of metalloendoproteases in the acrosome reaction in sea urchin sperm. J Biol Chem. 1987 Apr 25;262(12):5483-7.

[2]. Pinto MR, et al. Chymotrypsin-like enzymes are involved in sperm penetration through the vitelline coat of Ciona intestinalis egg. Mol Reprod Dev. 1990 Aug;26(4):319-23.

[3]. Mumford RA, et al. A zinc metalloendopeptidase associated with dog pancreatic membranes. J Biol Chem. 1980 Mar 25;255(6):2227-30.

Chemical & Physical Properties

[ Density]:
1.331g/cm3

[ Boiling Point ]:
1002.6ºC at 760 mmHg

[ Molecular Formula ]:
C₂₉H₃₂N₄O₈

[ Molecular Weight ]:
564.58600

[ Flash Point ]:
560.2ºC

[ Exact Mass ]:
564.22200

[ PSA ]:
183.91000

[ LogP ]:
2.88730

[ Index of Refraction ]:
1.607

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport