Irinotecan-d10

Names

[ Name ]:
Irinotecan-d10

Biological Activity

[Description]:

Irinotecan-d10 ((+)-Irinotecan-d10) is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. Morales C, et al. Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor. J Neurooncol. 2002 Feb;56(3):219-26.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₂₈D₁₀N₄O₆

[ Molecular Weight ]:
596.74

Related Compounds

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