<Suppliers Price>

ML 193

Names

[ CAS No. ]:
713121-80-3

[ Name ]:
ML 193

[Synonym ]:
4-Quinolinecarboxamide, N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-
N-{4-[(3,4-Dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl}-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
MFCD05999971

Biological Activity

[Description]:

ML193 (CID 1261822) is a potent, selective GPR55 antagonist with IC50 of 221 nM, shows >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively; reduces neuronal differentiation in vitro, increases anxiety-like behaviors while causing locomotor impairment by i.c.v. injection at the doses of 0.1 and 1 μg/rat.

[References]

References 1. Kotsikorou E, et al. Biochemistry. 2013 Dec 31;52(52):9456-69. 2. Munawar N, et al. Front Pharmacol. 2017 Mar 20;8:136. 3. Drzazga A, et al. Biochem Biophys Res Commun. 2017 Jul 22;489(2):242-247. 4. Hill JD, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14387. View Related Products by Target GPR55

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C28H25N5O4S

[ Molecular Weight ]:
527.594

[ Exact Mass ]:
527.162720

[ LogP ]:
4.63

[ Index of Refraction ]:
1.670

[ Storage condition ]:
-20°C

Related Compounds