oxfenicine

Names

[ Name ]:
oxfenicine

[Synonym ]:
(2S)-Amino(3-hydroxyphenyl)acetic acid
(S)-amino-(3-hydroxyphenyl)acetic acid
(2S)-(+)-2-(3-Hydroxyphenyl)glycin
(+)-o-fluorophenylglycine
Benzeneacetic acid, α-amino-3-hydroxy-, (αS)-
oxfenicine
2-(2-FLUOROPHENYL)GLYCINE
(aS)-a-Amino-4-hydroxybenzeneacetic Acid
Benzeneacetic acid, α-amino-4-hydroxy-, (αS)-
(2S)-amino(3-hydroxyphenyl)ethanoic acid
(S)-2-(3-Hydroxyphenyl)glycine
(2S)-Amino(4-hydroxyphenyl)acetic acid
(S)-a-Amino-4-hydroxybenzeneacetic Acid
(S)-AMINO-(2-FLUORO-PHENYL)-ACETIC ACID
Pyrrolidinedithiocarbamate ammonium
S-3-hydroxyphenylglycine
(S)-2-amino-2-(2-fluorophenyl)acetic acid
(2S)-amino(4-hydroxyphenyl)ethanoic acid

Biological Activity

[Description]:

(S)-3-Hydroxyphenylglycine ((S)-3HPG) is a potent mGluR1 agonist without effect at mGlu2 or mGlu4[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[References]

[1]. Y Hayashi, et al. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J Neurosci. 1994 May;14(5 Pt 2):3370-7.

[2]. Birse EF, et al. Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience. 1993 Feb;52(3):481-8.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
382.6±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₉NO₃

[ Molecular Weight ]:
167.162

[ Flash Point ]:
185.2±25.1 °C

[ Exact Mass ]:
167.058243

[ PSA ]:
83.55000

[ LogP ]:
0.20

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.633

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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