YUKA1

Names

[ Name ]:
YUKA1

Biological Activity

[Description]:

YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Demethylase

[Target]

IC50: 2.66 μM (KDM5A), 7.12 μM (KDM5C)[1]

[References]

[1]. Gale M, et al. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget. 2016 Jun 28;7(26):39931-39944.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₆N₄O₂S

[ Molecular Weight ]:
292.36