Cefpiramide acid

Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase[1][2].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

Bacterial[1][2]

Cefpiramide (0-2048 µg/mL; 16-18 hours) shows good activity to against most non-fermentative Gram-negative bacilli and Enterococci (32 µg/mL with 97% inhibition)[1]. Cefpiramide (0-2048 µg/mL; 16-18 hours) exhibits high effective to against Pseudomonas aeruginosa with MIC[50] and MIC[90] values of 4 µg/mL and 16 µg/mL separately[1]. Cell Viability Assay[1] Cell Line: 761 bacterial isolates (35 different species of common bacterial pathogens) Concentration: 0-2048 µg/mL Incubation Time: 16-18 hours Result: Showed broad-spectrum antibacterial activity.

Cefpiramide (25 mg/kg; i.v.; once) shows anti-Streptococcus pneumoniae activity in experimental pneumococcal meningitis[2]. Cefpiramide (25 mg/kg; i.v.; once) reduces bacteria in CSF more than 10[4] CFU/ml[2]. Animal Model: New Zealand white male rabbits(2-3 kg)[2]. Dosage: 25 mg/kg Administration: Intravenous injection; once. Result: Anti-Streptococcus pneumoniae.

[1]. Barry AL, et al. Cefpiramide: comparative in-vitro activity and beta-lactamase stability. J Antimicrob Chemother. 1985 Sep;16(3):315-25.

[2]. Sato K, et al. Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis. Antimicrob Agents Chemother. 1984 Oct;26(4):578-9.