TERT-BUTYL-BICYCLO [2.2.2]
Names
[ CAS No. ]:
70636-86-1
[ Name ]:
TERT-BUTYL-BICYCLO [2.2.2]
[Synonym ]:
tert-Butylbicyclophosphorothionate
TBPS
Chemical & Physical Properties
[ Density]:
1.25g/cm3
[ Boiling Point ]:
231.3ºC at 760 mmHg
[ Molecular Formula ]:
C8H15O3PS
[ Molecular Weight ]:
222.24200
[ Flash Point ]:
93.7ºC
[ Exact Mass ]:
222.04800
[ PSA ]:
69.59000
[ LogP ]:
2.97100
[ Index of Refraction ]:
1.52
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TG0782500
- CHEMICAL NAME :
- Phosphorothioic acid, cyclic O,O,O-ester with 2-(tert-butyl)-2-(hydroxymethyl)-1,3- propanediol
- CAS REGISTRY NUMBER :
- 70636-86-1
- LAST UPDATED :
- 199409
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C8-H15-O3-P-S
- MOLECULAR WEIGHT :
- 222.26
- WISWESSER LINE NOTATION :
- T66 A B AO EOPOTJ CX1&1&1 FS
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 53 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 47,287,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 55 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 38,1734,1990
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
TG0782500
Articles
Eur. J. Med. Chem. 43 , 107-13, (2008)
Allopregnanolone (1) and pregnanolone (2), steroids containing a 17beta-acetyl group, are potent enhancers of GABA (gamma-aminobutyric acid) action at GABAA receptors. Their effects are enantioselecti...
Synthesis and GABAAreceptor activity of A-homo analogues of neuroactive steroidsEur. J. Med. Chem. 45 , 3063-9, (2010)
A procedure is described for the preparation of A-homo-5-pregnenes via an acid catalyzed rearrangement of cyclopropylcarbinols assisted by microwave irradiation. 3α-Hydroxy and 4α-hydroxy-A-homo-5-pre...
Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates.Eur. J. Pharmacol. 519(1-2) , 31-42, (2005)
The effects of prolonged exposure to and subsequent withdrawal of the thienotriazolobenzodiazepine etizolam on gamma-aminobutyric acid (GABA) type A receptor gene expression and function were compared...