beta-L-D4A

Names

[ Name ]:
beta-L-D4A

[Synonym ]:
D4A
2',3'-Dideoxy-2'3'-didehy...
2'3'-didehydro-2'3'-dideoxyadenosine
((2S,5R)-5-(6-Amino-9H-purin-9-yl)-2,5-dihydrofuran-2-yl)methanol

Biological Activity

[Description]:

NSC 108602 is a nucleoside HIV-1 reverse transcriptase inhibitor.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[Target]

HIV-1

[In Vitro]

NSC 108602 (d4A) is a nucleoside HIV-1 reverse transcriptase inhibitor. Results confirm that the biological activity of NSC 108602 is connected with the termination of the DNA chain synthesis in the 5′-3′ direction[1].

[References]

[1]. Ponomareva AG, et al. Structural and energetic properties of the potential HIV-1 reverse transcriptase inhibitors d4A and d4G: a comprehensive theoretical investigation. J Biomol Struct Dyn. 2014;32(5):730-40.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.74 g/cm3

[ Boiling Point ]:
553.9ºC at 760 mmHg

[ Melting Point ]:
187-189ºC

[ Molecular Formula ]:
C₁₀H₁₁N₅O₂

[ Molecular Weight ]:
233.22700

[ Flash Point ]:
288.8ºC

[ Exact Mass ]:
233.09100

[ PSA ]:
99.08000

[ LogP ]:
0.43560

[ Index of Refraction ]:
1.822

Safety Information

[ Hazard Codes ]:
Xn

Precursor & DownStream

Precursor

DownStream

Related Compounds

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