Supercinnamaldehyde

Names

[ Name ]:
Supercinnamaldehyde

[Synonym ]:
Bicyclo[3.1.1]heptan-2-one,3-[3-(trimethylsilyl)-2-butenyl]
(3E)-1-methyl-3-(2-oxopropyridene)-1,3-dihydro-2H-indol-2-one
3-((E)-3-trimethylsilyl-2-butenyl)bicyclo[3.3.1]-heptan-2-one

Biological Activity

[Description]:

Supercinnamaldehyde is a potent transient receptor potential ankyrin 1 (TRPA1) activator with an EC50 value of 0.8 μM. Supercinnamaldehyde activates TRPA1 ion channels through covalent modification of cysteines[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Neurological Disease

[References]

[1]. Macpherson LJ, et, al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature. 2007 Feb 1;445(7127):541-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₁NO₂

[ Molecular Weight ]:
201.22

[ Exact Mass ]:
201.07900

[ PSA ]:
37.38000

[ LogP ]:
1.70040

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38-52/53

[ Safety Phrases ]:
26-36/37-61

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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